PDLIM5 polyclonal antibody (A02)
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More Files
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Western Blot (Cell lysate)
PDLIM5 polyclonal antibody (A02). Western Blot analysis of PDLIM5 expression in HepG2.
Western Blot detection against Immunogen (91.67 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length recombinant PDLIM5.
Immunogen
PDLIM5 (AAH08741, 1 a.a. ~ 596 a.a) full-length recombinant protein with GST tag.
Sequence
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTTAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSAAYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (91.67 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PDLIM5 polyclonal antibody (A02). Western Blot analysis of PDLIM5 expression in HepG2.Western Blot (Recombinant protein)
ELISA
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Gene Info — PDLIM5
Entrez GeneID
10611GeneBank Accession#
BC008741Protein Accession#
AAH08741Gene Name
PDLIM5
Gene Alias
ENH, ENH1, L9, LIM
Gene Description
PDZ and LIM domain 5
Omim ID
605904Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized. [provided by RefSeq
Other Designations
enigma homolog|enigma-like LIM domain protein
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Interactome
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Disease
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Publication Reference
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Nicotine Treatment Ameliorates Blood-Brain Barrier Damage After Acute Ischemic Stroke by Regulating Endothelial Scaffolding Protein Pdlim5.
Xiaoyan Hu , Jiali Dong, Panpan Geng , Yanyun Sun, Weihong Du, Xiaoyun Zhao, Qian Wang, Changqing Liu, Xiaona Wang, Yushan Liu, Wenlan Liu, Hongqiang Cheng, Wei Wang, Xinchun Jin.
Translational Stroke Research 2023 May; [Epub].
Application：WB, Mouse, bEND.3 cells, Mouse brain.
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p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.
Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE.
FASEB Journal 2019 Dec; 33(12):13131.
Application：WB, Mouse, Mouse hearts.
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Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy.
Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton KU, Peterson KL, Chen J.
Circulation Research 2010 Aug; 107(3):348.
Application：WB-Ti, Mouse, Mouse hearts.
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Nicotine Treatment Ameliorates Blood-Brain Barrier Damage After Acute Ischemic Stroke by Regulating Endothelial Scaffolding Protein Pdlim5.
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