CCT2 monoclonal antibody (M01), clone 2G6
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More Files
- More Functions
Western Blot (Cell lysate)
CCT2 monoclonal antibody (M01), clone 2G6 Western Blot analysis of CCT2 expression in A-431 ( Cat # L015V1 ).
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CCT2 is 0.03 ng/ml as a capture antibody.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CCT2 is approximately 0.3ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to CCT2 on A-431 cell. [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (36.85 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CCT2.
Immunogen
CCT2 (NP_006422, 117 a.a. ~ 217 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
IAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.85 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CCT2 monoclonal antibody (M01), clone 2G6 Western Blot analysis of CCT2 expression in A-431 ( Cat # L015V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CCT2 is 0.03 ng/ml as a capture antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CCT2 is approximately 0.3ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to CCT2 on A-431 cell. [antibody concentration 10 ug/ml] -
Gene Info — CCT2
Entrez GeneID
10576GeneBank Accession#
NM_006431Protein Accession#
NP_006422Gene Name
CCT2
Gene Alias
99D8.1, CCT-beta, CCTB, MGC142074, MGC142076, PRO1633, TCP-1-beta
Gene Description
chaperonin containing TCP1, subunit 2 (beta)
Omim ID
605139Gene Ontology
HyperlinkGene Summary
This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
T-complex protein 1 subunit beta|T-complex protein 1, beta subunit|chaperonin containing TCP1, subunit 2|chaperonin containing t-complex polypeptide 1, beta subunit|chaperonin containing t-complex polypeptide 1, subunit 2
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Interactome
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Disease
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Publication Reference
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Chaperonin-containing t-complex protein-1 subunit β as a possible biomarker for the phase of glomerular hyperfiltration of diabetic nephropathy.
Wu CZ, Chang LC, Lin YF, Hung YJ, Pei D, Chen JS.
Disease Markers 2012 Apr; 2015:548101.
Application：C-ELISA, Human, Human urine.
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Reconstitution of the human chaperonin CCT by co-expression of the eight distinct subunits in mammalian cells.
Machida K, Masutani M, Kobayashi T, Mikami S, Nishino Y, Miyazawa A, Imataka H.
Protein Expression and Purification 2012 Mar; 82(1):61.
Application：WB, Hamster, Human, BHK-21, HeLa cells.
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BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.
Seo S, Baye LM, Schulz NP, Beck JS, Zhang Q, Slusarski DC, Sheffield VC.
PNAS 2010 Jan; 107(4):1488.
Application：IF, WB-Ti, WB-Tr, Human, Mouse, ARPE-19 cells, Eyes, HEK 293T cells, Testes.
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Chaperonin-containing t-complex protein-1 subunit β as a possible biomarker for the phase of glomerular hyperfiltration of diabetic nephropathy.
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