SPTLC1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human SPTLC1 full-length ORF ( AAH07085, 43 a.a. - 143 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
TYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAATLASLKKYGVGTCGPRGFYGTFE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.85
Interspecies Antigen Sequence
Mouse (89); Rat (90)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SPTLC1
Entrez GeneID
10558GeneBank Accession#
BC007085Protein Accession#
AAH07085Gene Name
SPTLC1
Gene Alias
HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI
Gene Description
serine palmitoyltransferase, long chain base subunit 1
Gene Ontology
HyperlinkGene Summary
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000022810|OTTHUMP00000022811|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase subunit 1|serine-palmitoyl-CoA transferase 1
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Interactome
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Pathway
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Disease
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