PROCR (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PROCR full-length ORF ( AAH14451.1, 1 a.a. - 238 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGGFIIAGVAVGIFLCTGGRRC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
51.92
Interspecies Antigen Sequence
Mouse (65); Rat (67)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PROCR
Entrez GeneID
10544GeneBank Accession#
BC014451Protein Accession#
AAH14451.1Gene Name
PROCR
Gene Alias
CCCA, CCD41, CD201, EPCR, MGC23024, bA42O4.2
Gene Description
protein C receptor, endothelial (EPCR)
Omim ID
600646Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq
Other Designations
APC receptor|CD201 antigen|OTTHUMP00000030729|activated protein C receptor|cell cycle, centrosome-associated protein|centrocyclin|endothelial protein C receptor
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Interactome
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Disease
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Publication Reference
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Down-regulation of endothelial protein C receptor promotes preeclampsia by affecting actin polymerization.
Wang H, Wang P, Liang X, Li W, Yang M, Ma J, Yue W, Fan S.
Journal of Cellular and Molecular Medicine 2020 Mar; 24(6):3370.
Application:Func, Recombinant protein.
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Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo.
Kwak S, Han MS, Bae JS.
Fitoterapia 2015 Jan; 100:179.
Application:ELISA, Human, Mouse, Primary human umbilical vein endothelial cells (HUVECs), mouse plasma.
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Piperlonguminine Downregulates Endothelial Protein C Receptor Shedding In Vitro and In Vivo.
Ku SK, Kim JA, Bae JS.
Inflammation 2014 Apr; 37(2):435.
Application:ELISA, C-ELISA, Human, HUVECs.
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Mac-1 Directly Binds to the Endothelial Protein C-Receptor: A Link between the Protein C Anticoagulant Pathway and Inflammation?
Fink K, Busch HJ, Bourgeois N, Schwarz M, Wolf D, Zirlik A, Peter K, Bode C, von Zur Muhlen C.
PLoS One 2013 Feb; 8(2):e53103.
Application:FlowCyt, Human, Human monocyte.
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Down-regulation of endothelial protein C receptor promotes preeclampsia by affecting actin polymerization.
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