PROCR monoclonal antibody (M03), clone M2
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to PROCR on formalin-fixed paraffin-embedded human malignant lymphoma, diffuse large B tissue. [antibody concentration 3 ug/ml]
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PROCR is 3 ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to PROCR on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (51.92 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant PROCR.
Immunogen
PROCR (AAH14451.1, 1 a.a. ~ 238 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGGFIIAGVAVGIFLCTGGRRC
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (65); Rat (67)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (51.92 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to PROCR on formalin-fixed paraffin-embedded human malignant lymphoma, diffuse large B tissue. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PROCR is 3 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to PROCR on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — PROCR
Entrez GeneID
10544GeneBank Accession#
BC014451Protein Accession#
AAH14451.1Gene Name
PROCR
Gene Alias
CCCA, CCD41, CD201, EPCR, MGC23024, bA42O4.2
Gene Description
protein C receptor, endothelial (EPCR)
Omim ID
600646Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq
Other Designations
APC receptor|CD201 antigen|OTTHUMP00000030729|activated protein C receptor|cell cycle, centrosome-associated protein|centrocyclin|endothelial protein C receptor
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Interactome
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Disease
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Publication Reference
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Anti-inflammatory effects of hyperoside in human endothelial cells and in mice.
Ku SK, Zhou W, Lee W, Han MS, Na M, Bae JS.
Inflammation 2015 Apr; 38(2):784.
Application：ELISA, IHC, Human, Mouse, HUVEC, Blood vessels.
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Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo.
Kwak S, Han MS, Bae JS.
Fitoterapia 2015 Jan; 100:179.
Application：Competitive ELISA, Human, Mouse, Primary human umbilical vein endothelial cells (HUVECs), mouse plasma.
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Sulforaphane inhibits endothelial protein C receptor shedding in vitro and in vivo.
Ku SK, Han MS, Bae JS.
Vascular Pharmacology 2014 Oct; 63(1):13.
Application：ELISA, Human, HUVECs.
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Inhibitory effects of epi-sesamin on endothelial protein C receptor shedding in vitro and in vivo.
Ku SK, Lee W, Yoo H, Han CK, Bae JS.
Inflammation Research 2013 Oct; 62(10):895.
Application：ELISA, Human, HUVECs.
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Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo.
Ku SK, Yang EJ, Song KS, Bae JS.
Food and Chemical Toxicology 2013 Sep; 59:311.
Application：ELISA, C-ELISA, Human, Mouse, HUVECs, Serum.
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Down-regulation of endothelial protein C receptor shedding by persicarin and isorhamnetin-3-O-galactoside.
Ku SK, Han MS, Bae JS.
Thrombosis Research 2013 Jul; 132(1):e58.
Application：ELISA, C-ELISA, Human, HUVECs, Supernatants collected from HUVECs culture medium.
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Emodin-6-O-β-D-glucoside down-regulates endothelial protein C receptor shedding.
Lee W, Ku SK, Bae JS.
Archives of Pharmacal Research 2013 Sep; 36(9):1160.
Application：C-ELISA, Human, Mouse, HUVECs, Mouse serum.
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Anti-inflammatory effects of hyperoside in human endothelial cells and in mice.
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