PROCR purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PROCR protein.
Immunogen
PROCR (NP_006395.2, 1 a.a. ~ 238 a.a) full-length human protein.
Sequence
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (65); Rat (67)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PROCR expression in transfected 293T cell line (H00010544-T02) by PROCR MaxPab polyclonal antibody.
Lane 1: PROCR transfected lysate(26.70 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PROCR
Entrez GeneID
10544GeneBank Accession#
NM_006404.3Protein Accession#
NP_006395.2Gene Name
PROCR
Gene Alias
CCCA, CCD41, CD201, EPCR, MGC23024, bA42O4.2
Gene Description
protein C receptor, endothelial (EPCR)
Omim ID
600646Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq
Other Designations
APC receptor|CD201 antigen|OTTHUMP00000030729|activated protein C receptor|cell cycle, centrosome-associated protein|centrocyclin|endothelial protein C receptor
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Interactome
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Disease
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Publication Reference
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Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells.
Chunye Liu, Changdong Lin, Daisong Wang, Jingqiang Wang, Yu Tao, Yue Li, Xinyi Chen, Lanyue Bai, Yingying Jia, Jianfeng Chen, Yi Arial Zeng.
Cell Reports 2022 Mar; 38(12):110548.
Application:WB, Mouse, Mammary glands.
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Piperlonguminine Downregulates Endothelial Protein C Receptor Shedding In Vitro and In Vivo.
Ku SK, Kim JA, Bae JS.
Inflammation 2014 Apr; 37(2):435.
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Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells.
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