RNASEH2A 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RNASEH2A full-length
Host
Human
Theoretical MW (kDa)
33
Interspecies Antigen Sequence
Rat (84)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RNASEH2A antibody (H00010535-B01) by Western Blots.
Western Blot
Lane 1: RNASEH2A transfected lysate ( 33.4 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
RNASEH2A transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RNASEH2A
Entrez GeneID
10535GeneBank Accession#
NM_006397Protein Accession#
NP_006388Gene Name
RNASEH2A
Gene Alias
AGS4, JUNB, RNASEHI, RNHIA, RNHL
Gene Description
ribonuclease H2, subunit A
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid
Other Designations
ribonuclease H2, large subunit|ribonuclease HI, large subunit
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