HYOU1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HYOU1 full-length
Host
Human
Theoretical MW (kDa)
74.69
Interspecies Antigen Sequence
Mouse (93); Rat (93)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HYOU1 antibody (H00010525-B01) by Western Blots.
SDS-PAGE Gel
HYOU1 transfected lysate.
Western Blot
Lane 1: HYOU1 transfected lysate ( 74.69 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HYOU1
Entrez GeneID
10525GeneBank Accession#
BC072436.1Protein Accession#
AAH72436.1Gene Name
HYOU1
Gene Alias
DKFZp686N08236, FLJ94899, FLJ97572, Grp170, HSP12A, ORP150
Gene Description
hypoxia up-regulated 1
Omim ID
601746Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq
Other Designations
150 kDa oxygen-regulated protein|glucose-regulated protein 170|oxygen regulated protein (150kD)
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Interactome
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