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HYOU1 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00010525-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-HYOU1 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 74.69
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-HYOU1 antibody (H00010525-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00010525-T01
    HYOU1 transfected lysate.
    Western Blot
    QC Testing of H00010525-T01
    Lane 1: HYOU1 transfected lysate ( 74.69 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • HYOU1
  • Gene Alias:
  • DKFZp686N08236,FLJ94899,FLJ97572,Grp170,HSP12A,ORP150
  • Gene Description:
  • hypoxia up-regulated 1
  • Gene Summary:
  • The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq
  • Other Designations:
  • 150 kDa oxygen-regulated protein,glucose-regulated protein 170,oxygen regulated protein (150kD)
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