HYOU1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human HYOU1 full-length ORF ( AAH04560.1, 36 a.a. - 147 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
38.06
Interspecies Antigen Sequence
Mouse (93); Rat (93)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — HYOU1
Entrez GeneID
10525GeneBank Accession#
BC004560Protein Accession#
AAH04560.1Gene Name
HYOU1
Gene Alias
DKFZp686N08236, FLJ94899, FLJ97572, Grp170, HSP12A, ORP150
Gene Description
hypoxia up-regulated 1
Omim ID
601746Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq
Other Designations
150 kDa oxygen-regulated protein|glucose-regulated protein 170|oxygen regulated protein (150kD)
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Interactome
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Disease
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