HTATIP (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human HTATIP full-length ORF ( AAH00166, 1 a.a. - 461 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
76.34
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — KAT5
Entrez GeneID
10524GeneBank Accession#
BC000166.2Protein Accession#
AAH00166Gene Name
KAT5
Gene Alias
ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, cPLA2
Gene Description
K(lysine) acetyltransferase 5
Omim ID
601409Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
Other Designations
HIV-1 Tat interactive protein, 60kDa|K-acetyltransferase 5|Tat interacting protein, 60kDa|cPLA2 interacting protein
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Interactome
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Publication Reference
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Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.
Kurash JK, Lei H, Shen Q, Marston WL, Granda BW, Fan H, Wall D, Li E, Gaudet F.
Molecular Cell 2008 Feb; 29(3):392.
Application:IP, PI, WB, Human, HCT-116, Recombinant protein.
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Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.
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