UNC13B polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (38.21 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant UNC13B.
Immunogen
UNC13B (NP_006368, 1482 a.a. ~ 1591 a.a) partial recombinant protein with GST tag.
Sequence
SKSNNWAPKYNETFHLLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (92)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — UNC13B
Entrez GeneID
10497GeneBank Accession#
NM_006377Protein Accession#
NP_006368Gene Name
UNC13B
Gene Alias
MGC133279, MGC133280, MUNC13, UNC13, Unc13h2, hmunc13
Gene Description
unc-13 homolog B (C. elegans)
Omim ID
605836Gene Ontology
HyperlinkGene Summary
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq
Other Designations
OTTHUMP00000021327|UNC13 (C. elegans)-like|homolog of rat Munc13 (diacylglycerol-binding)|unc-13-like
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Interactome
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Disease
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