BAIAP2 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-BAIAP2 full-length
Host
Human
Theoretical MW (kDa)
60.9
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-BAIAP2 antibody (H00010458-D01P) by Western Blots.
SDS-PAGE Gel
BAIAP2 transfected lysate.
Western Blot
Lane 1: BAIAP2 transfected lysate ( 60.90 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — BAIAP2
Entrez GeneID
10458GeneBank Accession#
NM_017451Protein Accession#
NP_059345.1Gene Name
BAIAP2
Gene Alias
BAP2, IRSP53
Gene Description
BAI1-associated protein 2
Omim ID
605475Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms
Other Designations
insulin receptor substrate p53
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Interactome
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Pathway
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Disease
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