GPNMB rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human GPNMB peptide using ARM Technology.
Immunogen
A synthetic peptide of human GPNMB is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human GPNMB peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — GPNMB
Entrez GeneID
10457GeneBank Accession#
GPNMBGene Name
GPNMB
Gene Alias
HGFIN, NMB
Gene Description
glycoprotein (transmembrane) nmb
Omim ID
604368Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
glycoprotein NMB|glycoprotein nmb-like protein|osteoactivin|transmembrane glycoprotein
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Interactome
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Disease
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