Western blot analysis of TESK2 over-expressed 293 cell line, cotransfected with TESK2 Validated Chimera RNAi ( Cat # H00010420-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TESK2 monoclonal antibody (M01) clone 1A8 (Cat # H00010420-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. [provided by RefSeq
OTTHUMP00000009093,testis-specific protein kinase 2