KNTC2 monoclonal antibody (M01), clone 1A10
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More Files
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Western Blot (Cell lysate)
KNTC2 monoclonal antibody (M01), clone 1A10 Western Blot analysis of KNTC2 expression in Hela S3 NE ( Cat # L013V3 ).
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged KNTC2 is approximately 0.1ng/ml as a capture antibody.
Western Blot detection against Immunogen (36.19 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant KNTC2.
Immunogen
KNTC2 (AAH35617, 545 a.a. ~ 642 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
TVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (83); Rat (84)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.19 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
KNTC2 monoclonal antibody (M01), clone 1A10 Western Blot analysis of KNTC2 expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged KNTC2 is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — NDC80
Entrez GeneID
10403GeneBank Accession#
BC035617Protein Accession#
AAH35617Gene Name
NDC80
Gene Alias
HEC, HEC1, KNTC2, TID3, hsNDC80
Gene Description
NDC80 homolog, kinetochore complex component (S. cerevisiae)
Omim ID
607272Gene Ontology
HyperlinkGene Summary
HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM
Other Designations
highly expressed in cancer, rich in leucine heptad repeats|kinetochore associated 2
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Interactome
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Disease
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Publication Reference
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Proinvasion metastasis drivers in early-stage melanoma are oncogenes.
Scott KL, Nogueira C, Heffernan TP, van Doorn R, Dhakal S, Hanna JA, Min C, Jaskelioff M, Xiao Y, Wu CJ, Cameron LA, Perry SR, Zeid R, Feinberg T, Kim M, Vande Woude G, Granter SR, Bosenberg M, Chu GC, Depinho RA, Rimm DL, Chin L.
Cancer Cell 2011 Jul; 20:92.
Application：IF, Human, Melanoma.
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Proinvasion metastasis drivers in early-stage melanoma are oncogenes.
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