Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

TNK2

Gene Alias

ACK, ACK1, FLJ44758, FLJ45547, p21cdc42Hs

Gene Description

tyrosine kinase, non-receptor, 2

Omim ID

Gene Ontology

Gene Summary

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq

Other Designations

activated Cdc42-associated kinase 1|activated p21cdc42Hs kinase