Products

Western Blot (Transfected lysate)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

RASA4

Gene Alias

CAPRI, GAPL, KIAA0538, MGC131890

Gene Description

RAS p21 protein activator 4

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

Ca2+-promoted Ras inactivator|Ras GTPase-activating protein 4|calcium-promoted Ras inactivator