TOB1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
Western Blot
Lane 1: TOB1 transfected lysate ( 38.2 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
TOB1 transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TOB1 full-length
Host
Human
Theoretical MW (kDa)
38.06
Interspecies Antigen Sequence
Mouse (91); Rat (91)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TOB1 antibody (H00010140-B01) by Western Blots.
Western Blot
Lane 1: TOB1 transfected lysate ( 38.2 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
TOB1 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TOB1
Entrez GeneID
10140GeneBank Accession#
NM_005749Protein Accession#
NP_005740Gene Name
TOB1
Gene Alias
APRO6, MGC104792, MGC34446, PIG49, TOB, TROB, TROB1
Gene Description
transducer of ERBB2, 1
Omim ID
605523Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. [provided by RefSeq
Other Designations
transducer of erbB-2
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