OPTN 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
OPTN transfected lysate.
Western Blot
Lane 1: OPTN transfected lysate ( 65.9 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-OPTN full-length
Host
Human
Theoretical MW (kDa)
65.9
Interspecies Antigen Sequence
Mouse (76); Rat (73)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-OPTN antibody (H00010133-B01) by Western Blots.
SDS-PAGE Gel
OPTN transfected lysate.
Western Blot
Lane 1: OPTN transfected lysate ( 65.9 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — OPTN
Entrez GeneID
10133GeneBank Accession#
NM_001008211Protein Accession#
NP_001008212Gene Name
OPTN
Gene Alias
FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Gene Description
optineurin
Gene Ontology
HyperlinkGene Summary
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
Huntingtin interacting protein L|OTTHUMP00000019125|OTTHUMP00000019126|OTTHUMP00000019127|OTTHUMP00000019128|glaucoma 1, open angle, E (adult-onset)|nemo-related protein|transcrption factor IIIA-interacting protein|tumor necrosis factor alpha-inducible ce
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Interactome
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Disease
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