OPTN MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of OPTN expression in transfected 293T cell line (H00010133-T02) by OPTN MaxPab polyclonal antibody.
Lane 1: OPTN transfected lysate(65.90 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of OPTN transfected lysate using anti-OPTN MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with OPTN purified MaxPab mouse polyclonal antibody (B01P) (H00010133-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human OPTN protein.
Immunogen
OPTN (NP_001008212.1, 1 a.a. ~ 577 a.a) full-length human protein.
Sequence
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (76); Rat (73)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of OPTN expression in transfected 293T cell line (H00010133-T02) by OPTN MaxPab polyclonal antibody.
Lane 1: OPTN transfected lysate(65.90 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of OPTN transfected lysate using anti-OPTN MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with OPTN purified MaxPab mouse polyclonal antibody (B01P) (H00010133-B01P). -
Gene Info — OPTN
Entrez GeneID
10133GeneBank Accession#
NM_001008211Protein Accession#
NP_001008212.1Gene Name
OPTN
Gene Alias
FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Gene Description
optineurin
Gene Ontology
HyperlinkGene Summary
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
Huntingtin interacting protein L|OTTHUMP00000019125|OTTHUMP00000019126|OTTHUMP00000019127|OTTHUMP00000019128|glaucoma 1, open angle, E (adult-onset)|nemo-related protein|transcrption factor IIIA-interacting protein|tumor necrosis factor alpha-inducible ce
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Interactome
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Disease
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