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Last updated: 2016/12/4

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RASGRP1 rabbit monoclonal antibody

  • Catalog # : H00010125-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human RASGRP1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human RASGRP1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human RASGRP1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Gene Name:
  • RASGRP1
  • Gene Alias:
  • CALDAG-GEFI,CALDAG-GEFII,MGC129998,MGC129999,RASGRP,V,hRasGRP1
  • Gene Description:
  • RAS guanyl releasing protein 1 (calcium and DAG-regulated)
  • Gene Summary:
  • This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq
  • Other Designations:
  • RAS guanyl nucleotide-releasing protein 1,RAS guanyl releasing protein 1,calcium and DAG-regulated guanine nucleotide exchange factor II,guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A,ras activator RasGRP
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