IL18BP (Human) Recombinant Protein (P01)
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Specification
Product Description
Human IL18BP full-length ORF ( AAH44215, 31 a.a. - 194 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
TPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
43.78
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — IL18BP
Entrez GeneID
10068GeneBank Accession#
BC044215Protein Accession#
AAH44215Gene Name
IL18BP
Gene Alias
IL18BPa
Gene Description
interleukin 18 binding protein
Omim ID
604113Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
MC51L-53L-54L homolog gene product|OTTHUMP00000179141|OTTHUMP00000179143
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Disease
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