COX17 monoclonal antibody (M01), clone 4G2
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant COX17.
Immunogen
COX17 (NP_005685, 1 a.a. ~ 63 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (92); Rat (92)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (32.67 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
COX17 monoclonal antibody (M01), clone 4G2. Western Blot analysis of COX17 expression in IMR-32.Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to COX17 on formalin-fixed paraffin-embedded human heart. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged COX17 is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — COX17
Entrez GeneID
10063GeneBank Accession#
NM_005694Protein Accession#
NP_005685Gene Name
COX17
Gene Alias
MGC104397, MGC117386
Gene Description
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
Omim ID
604813Gene Ontology
HyperlinkGene Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq
Other Designations
COX17 homolog, cytochrome c oxidase assembly protein|human homolog of yeast mitochondrial copper recruitment
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Interactome
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Pathway
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Publication Reference
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Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.
Tokuda E, Okawa E, Watanabe S, Ono SI, Marklund SL.
Neurobiology of Disease 2013 Jan; 54:308.
Application:WB, Mouse, Lumbar spinal cords.
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Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.
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