NR1H3 monoclonal antibody (M08), clone 3E9
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant NR1H3.
Immunogen
NR1H3 (AAH08819, 1 a.a. ~ 387 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (68.31 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of NR1H3 expression in transfected 293T cell line by NR1H3 monoclonal antibody (M08), clone 3E9.
Lane 1: NR1H3 transfected lysate(45.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged NR1H3 is 3 ng/ml as a capture antibody.ELISA
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Gene Info — NR1H3
Entrez GeneID
10062GeneBank Accession#
BC008819Protein Accession#
AAH08819Gene Name
NR1H3
Gene Alias
LXR-a, LXRA, RLD-1
Gene Description
nuclear receptor subfamily 1, group H, member 3
Omim ID
602423Gene Ontology
HyperlinkGene Summary
group H
Other Designations
liver X receptor alpha|liver X receptor, alpha|liver X receptor-alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
Ishibashi M, Filomenko R, Rebe C, Chevriaux A, Varin A, Derangere V, Bessede G, Gambert P, Lagrost L, Masson D.
Biochemical Pharmacology 2013 Jan; 86(1):122.
Application:WB, Human, Human primary macrophages.
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Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
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