DNM1L (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human DNM1L full-length ORF ( AAH24590.1, 1 a.a. - 710 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
103.84
Interspecies Antigen Sequence
Mouse (97); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DNM1L
Entrez GeneID
10059GeneBank Accession#
BC024590Protein Accession#
AAH24590.1Gene Name
DNM1L
Gene Alias
DLP1, DRP1, DVLP, DYMPLE, DYNIV-11, FLJ41912, HDYNIV, VPS1
Gene Description
dynamin 1-like
Omim ID
603850Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. [provided by RefSeq
Other Designations
Dnm1p/Vps1p-like protein|dynamin 1-like protein|dynamin family member proline-rich carboxyl-terminal domain less|dynamin-like protein 4|dynamin-like protein IV|dynamin-related protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
Wang X, Chen Z, Fan X, Li W, Qu J, Dong C, Wang Z, Ji Z, Li Y.
Journal of Cellular and Molecular Medicine 2020 Jan; 24(2):1516.
Application:Func, Recombinant protein.
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Dynamin-like protein 1 cleavage by calpain in Alzheimer's disease.
Jiang S, Shao C, Tang F, Wang W, Zhu X.
Aging Cell 2019 Feb; e12912.
Application:Func, Calpain-1.
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A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D.
Nature Communications 2019 Jan; 10(1):329.
Application:WB, Rat, Rat cardiomyocytes.
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Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease.
Roe AJ, Qi X.
Biochemical and Biophysical Research Communications 2018 Feb; [Epub].
Application:Mass spectrometry, Mouse, HdhQ7 cells, Q111 cells.
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Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X.
The Journal of Clinical Investigation 2013 Dec; 123(12):5371.
Application:IF, IP, WB-Ce, WB-Tr, Human, Mouse, Striatal, HEK 293T cells, Fibroblasts.
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Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation.
Su YC, Qi X.
Human Molecular Genetics 2013 Nov; 22(22):4545.
Application:Func, PI, Recombinant protein.
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A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Qi X, Qvit N, Su YC, Mochly-Rosen D.
Journal of Cell Science 2013 Feb; 126(Pt 3):789.
Application:IF, IP-WB, WB-Ce, Human, SH-SY5Y cells.
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Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.
Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D.
Molecular Biology of the Cell 2011 Jan; 22(2):256.
Application:Func, Recombinant protein.
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Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
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