GNE 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
GNE transfected lysate.
Western Blot
Lane 1: GNE transfected lysate ( 79.30 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-GNE full-length
Host
Human
Theoretical MW (kDa)
79.3
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-GNE antibody (H00010020-D01P) by Western Blots.
SDS-PAGE Gel
GNE transfected lysate.
Western Blot
Lane 1: GNE transfected lysate ( 79.30 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — GNE
Entrez GeneID
10020GeneBank Accession#
NM_005476.3Protein Accession#
NP_005467.1Gene Name
GNE
Gene Alias
DMRV, GLCNE, IBM2, NM, Uae1
Gene Description
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
N-acylmannosamine kinase|OTTHUMP00000021370|UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase|UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
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Interactome
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Pathway
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Disease
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