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Last updated: 2017/12/10

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GNE 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00010020-T01
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-GNE full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 79.3
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-GNE antibody (H00010020-D01P) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00010020-T01
    GNE transfected lysate.
    Western Blot
    QC Testing of H00010020-T01
    Lane 1: GNE transfected lysate ( 79.30 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • GNE
  • Gene Alias:
  • DMRV,GLCNE,IBM2,NM,Uae1
  • Gene Description:
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Gene Summary:
  • The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • N-acylmannosamine kinase,OTTHUMP00000021370,UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase,UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
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