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GNE Pre-design Chimera RNAi

  • Catalog # : H00010020-R02
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_005476
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Gene Name:
  • GNE
  • Gene Alias:
  • DMRV,GLCNE,IBM2,NM,Uae1
  • Gene Description:
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Gene Summary:
  • The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • N-acylmannosamine kinase,OTTHUMP00000021370,UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase,UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
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