Products

Western Blot (Tissue lysate)

Western Blot (Cell lysate)

Western Blot (Transfected lysate)

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PDCD6IP

Gene Alias

AIP1, Alix, DRIP4, HP95, MGC17003

Gene Description

programmed cell death 6 interacting protein

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

ALG-2 interacting protein 1|ALG-2 interacting protein X|apoptosis-linked gene 2-interacting protein X|dopamine receptor interacting protein 4|programmed cell death 6-interacting protein