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DMTF1 Pre-design Chimera RNAi

  • Catalog # : H00009988-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens cyclin D binding myb-like transcription factor 1 (DMTF1), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_021145
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 9988
  • Gene Name:
  • DMTF1
  • Gene Alias:
  • DMP1,DMTF,FLJ25188,FLJ41265,FLJ76054,hDMP1
  • Gene Description:
  • cyclin D binding myb-like transcription factor 1
  • Gene Summary:
  • This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • cyclin D-binding Myb-like protein 1
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