NR1I3 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-NR1I3 full-length
Host
Human
Theoretical MW (kDa)
39.9
Interspecies Antigen Sequence
Mouse (73); Rat (78)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-NR1I3 antibody (H00009970-D01) by Western Blots.
SDS-PAGE Gel
NR1I3 transfected lysate.
Western Blot
Lane 1: NR1I3 transfected lysate ( 39.9 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — NR1I3
Entrez GeneID
9970GeneBank Accession#
BC069626.1Protein Accession#
NP_001070948.1Gene Name
NR1I3
Gene Alias
CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
Gene Description
nuclear receptor subfamily 1, group I, member 3
Omim ID
603881Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000032245|OTTHUMP00000032246|constitutive activator of retinoid response|constitutive active receptor|constitutive androstane receptor|orphan nuclear hormone receptor
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