NR1I3 (Human) IP-WB Antibody Pair
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (73); Rat (78)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of NR1I3 transfected lysate using rabbit polyclonal anti-NR1I3 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-NR1I3.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-NR1I3 (300 ul)
2. Antibody pair for WB: mouse purified polyclonal anti-NR1I3 (50 ug)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — NR1I3
Entrez GeneID
9970Gene Name
NR1I3
Gene Alias
CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
Gene Description
nuclear receptor subfamily 1, group I, member 3
Omim ID
603881Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000032245|OTTHUMP00000032246|constitutive activator of retinoid response|constitutive active receptor|constitutive androstane receptor|orphan nuclear hormone receptor
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