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MED12 Pre-design Chimera RNAi

  • Catalog # : H00009968-R01
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  • Specification
  • Product Description:
  • Homo sapiens mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) (MED12), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_005120
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 9968
  • Gene Name:
  • MED12
  • Gene Alias:
  • Gene Description:
  • mediator complex subunit 12
  • Gene Summary:
  • The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq
  • Other Designations:
  • FG syndrome 1,OPA-containing protein,OTTHUMP00000023491,mediator of RNA polymerase II transcription, subunit 12 homolog,thyroid hormone receptor-associated protein, 230 kDa subunit,trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subuni
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