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MED12 (Human) Recombinant Protein (Q01)

  • Catalog # : H00009968-Q01
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Human MED12 partial ORF ( NP_005111, 1829 a.a. - 1941 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • QPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVP
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 38.17
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00009968-Q01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 9968
  • Gene Name:
  • MED12
  • Gene Alias:
  • CAGH45,FGS1,HOPA,KIAA0192,OKS,OPA1,TNRC11,TRAP230
  • Gene Description:
  • mediator complex subunit 12
  • Gene Summary:
  • The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq
  • Other Designations:
  • FG syndrome 1,OPA-containing protein,OTTHUMP00000023491,mediator of RNA polymerase II transcription, subunit 12 homolog,thyroid hormone receptor-associated protein, 230 kDa subunit,trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subuni
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