Products

Western Blot

Enzyme-linked Immunoabsorbent Assay

SDS-PAGE

Protein Interaction

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

TNFSF15

Gene Alias

MGC129934, MGC129935, TL1, TL1A, VEGI, VEGI192A

Gene Description

tumor necrosis factor (ligand) superfamily, member 15

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq

Other Designations

OTTHUMP00000022739|TNF ligand-related molecule 1|TNF superfamily ligand TL1A|vascular endothelial cell growth inhibitor|vascular endothelial growth inhibitor-192A