ZFHX1B monoclonal antibody (M03), clone 2D12
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ZFHX1B.
Immunogen
ZFHX1B (NP_055610.1, 1115 a.a. ~ 1214 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (97)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.11 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
ZFHX1B monoclonal antibody (M03), clone 2D12. Western Blot analysis of ZFHX1B expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to ZFHX1B on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — ZEB2
Entrez GeneID
9839GeneBank Accession#
NM_014795.2Protein Accession#
NP_055610.1Gene Name
ZEB2
Gene Alias
KIAA0569, SIP-1, SIP1, SMADIP1, ZFHX1B
Gene Description
zinc finger E-box binding homeobox 2
Gene Ontology
HyperlinkGene Summary
The SMADIP1 gene (also known as SIP1) is a member of the delta-EF1 (ZEB1; MIM 189909)/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMADs (see MIM 605568) (Verschueren et al., 1999 [PubMed 10400677]).[supplied by OMIM
Other Designations
Smad interacting-protein 1|Smad-interacting protein 1|zinc finger E-box-binding protein 2|zinc finger homeobox 1b
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Interactome
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Disease
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Publication Reference
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Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.
Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt M, Strobl H.
European Journal of Immunology 2014 Feb; 44(2):553.
Application:IF, Human, Langerhans cells.
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The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.
Pogribny IP, Muskhelishvili L, Tryndyak VP, Beland FA.
Toxicology and Applied Pharmacology 2009 Mar; 235(3):305.
Application:WB, Rat, Livers.
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Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.
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