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Last updated: 2017/7/23

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ESPL1 Pre-design Chimera RNAi

  • Catalog # : H00009700-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens testis-specific transcript, Y-linked 22 (TTTY22) on chromosome Y.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_012291
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 9700
  • Gene Name:
  • ESPL1
  • Gene Alias:
  • ESP1,FLJ46492,KIAA0165,SEPARASE,SEPARIN
  • Gene Description:
  • extra spindle pole bodies homolog 1 (S. cerevisiae)
  • Gene Summary:
  • Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM
  • Other Designations:
  • extra spindle poles like 1,separin, separase
  • Gene Pathway
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