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ESPL1 (Human) Recombinant Protein (Q01)

  • Catalog # : H00009700-Q01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human ESPL1 partial ORF ( NP_036423, 586 a.a. - 701 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • REELQAYKAVRADTGQERFNIICDLLELSPEETPAGAWARATHLVELAQVLCYHDFTQQTNCSALDAIREALQLLDSVRPEAQARDQLLDDKAQALLWLYICTLEAKIQEGIERDR
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 38.5
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00009700-Q01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 9700
  • Gene Name:
  • ESPL1
  • Gene Alias:
  • ESP1,FLJ46492,KIAA0165,SEPARASE,SEPARIN
  • Gene Description:
  • extra spindle pole bodies homolog 1 (S. cerevisiae)
  • Gene Summary:
  • Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM
  • Other Designations:
  • extra spindle poles like 1,separin, separase
  • Gene Pathway
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