RAPGEF2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human RAPGEF2 partial ORF ( XP_376350, 1398 a.a. - 1487 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
PITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.64
Interspecies Antigen Sequence
Mouse (67); Rat (68)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RAPGEF2
Entrez GeneID
9693GeneBank Accession#
XM_376350Protein Accession#
XP_376350Gene Name
RAPGEF2
Gene Alias
CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, Rap-GEP
Gene Description
Rap guanine nucleotide exchange factor (GEF) 2
Omim ID
609530Gene Ontology
HyperlinkGene Summary
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM
Other Designations
PDZ domain containing guanine nucleotide exchange factor (GEF) 1|RA(Ras/Rap1A-associating)-GEF|Rap guanine nucleotide exchange factor 2
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Interactome
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Pathway
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