Products

Western Blot (Tissue lysate)

Western Blot (Tissue lysate)

Western Blot (Cell lysate)

Western Blot (Transfected lysate)

Immunoprecipitation

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PTGES

Gene Alias

MGC10317, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1

Gene Description

prostaglandin E synthase

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq

Other Designations

MGST1-like 1|OTTHUMP00000022345|glutathione S-transferase 1-like 1|microsomal glutathione S-transferase 1-like 1|microsomal prostaglandin E synthase-1|p53-induced apoptosis protein 12|p53-induced gene 12|tumor protein p53 inducible protein 12