BAG3 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human BAG3 full-length ORF ( AAH14656.1, 1 a.a. - 575 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSAATHSPMMQVASGNGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPKETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEAAAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAAQPPASHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYISIPVIHEQNVTRPAAQPSFHQAQKTHYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRVHTVVDRPQQPMTHRETAPVSQPENKPESKPGPVGPELPPGHIPIQVIRKEVDSKPVSQKPPPPSEKVEVKVPPAPVPCPPPSPGPSAVPSSPKSVATEERAAPSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAGNAEDPHTETQQPEATAAATSNPSSMTDTPGNPAAP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
88.99
Interspecies Antigen Sequence
Mouse (84); Rat (85)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — BAG3
Entrez GeneID
9531GeneBank Accession#
BC014656Protein Accession#
AAH14656.1Gene Name
BAG3
Gene Alias
BAG-3, BIS, CAIR-1, MGC104307
Gene Description
BCL2-associated athanogene 3
Omim ID
603883Gene Ontology
HyperlinkGene Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq
Other Designations
BAG-family molecular chaperone regulator-3|BCL2-binding athanogene 3|Bcl-2-binding protein|OTTHUMP00000020599|docking protein CAIR-1
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Interactome
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Disease
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Publication Reference
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BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.
Heng Lin, Sarah Sandkuhler, Colleen Dunlea, Darron H King, Gail V W Johnson.
bioRxiv : the Preprint Server for Biology 2023 Feb; 2023.02.08.527546.
Application：Pull-Down, Recombinant proteins.
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BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity.
Chen Y, Yang LN, Cheng L, Tu S, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F.
Molecular & Cellular Proteomics 2013 Oct; 12(10):2804.
Application：Func, SPR, Antibody.
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BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.
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