VPS4B polyclonal antibody (A01)
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More Files
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Western Blot (Cell lysate)
VPS4B polyclonal antibody (A01), Lot # 051206JC01 Western Blot analysis of VPS4B expression in Y-79 ( Cat # L042V1 ).
Western Blot detection against Immunogen (74.95 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length recombinant VPS4B.
Immunogen
VPS4B (AAH39574, 1 a.a. ~ 444 a.a) full-length recombinant protein with GST tag.
Sequence
MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDFGQEG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (95)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (74.95 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
VPS4B polyclonal antibody (A01), Lot # 051206JC01 Western Blot analysis of VPS4B expression in Y-79 ( Cat # L042V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — VPS4B
Entrez GeneID
9525GeneBank Accession#
BC039574Protein Accession#
AAH39574Gene Name
VPS4B
Gene Alias
MIG1, SKD1, VPS4-2
Gene Description
vacuolar protein sorting 4 homolog B (S. cerevisiae)
Omim ID
609983Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq
Other Designations
cell migration-inducing 1|suppressor of K+ transport defect 1|vacuolar protein sorting 4B|vacuolar protein sorting factor 4B
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Interactome
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Pathway
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Publication Reference
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Identification of an AAA ATPase VPS4B-Dependent Pathway That Modulates Epidermal Growth Factor Receptor Abundance and Signaling during Hypoxia.
Lin HH, Li X, Chen JL, Sun X, Cooper FN, Chen YR, Zhang W, Chung Y, Li A, Cheng CT, Yang L, Deng X, Liu X, Yen Y, Johnson DL, Shih HM, Yang A, Ann DK.
Molecular and Cellular Biology 2012 Jan; 32(6):1124.
Application：WB-Ce, Human, HEK293, SKBR3, Pa-4.
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The ESCRT System Is Required for Hepatitis C Virus Production.
Ariumi Y, Kuroki M, Maki M, Ikeda M, Dansako H, Wakita T, Kato N.
PLoS One 2011 Jan; 6(1):e14517.
Application：WB, Human, Huh7 cells.
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Identification of an AAA ATPase VPS4B-Dependent Pathway That Modulates Epidermal Growth Factor Receptor Abundance and Signaling during Hypoxia.
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