ADAMTS4 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ADAMTS4 full-length
Host
Human
Theoretical MW (kDa)
36
Interspecies Antigen Sequence
Rat (84)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ADAMTS4 antibody (H00009507-B01) by Western Blots.
SDS-PAGE Gel
ADAMTS4 transfected lysate.
Western Blot
Lane 1: ADAMTS4 transfected lysate ( 36 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ADAMTS4
Entrez GeneID
9507GeneBank Accession#
BC030812.1Protein Accession#
-Gene Name
ADAMTS4
Gene Alias
ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
Gene Description
ADAM metallopeptidase with thrombospondin type 1 motif, 4
Omim ID
603876Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq
Other Designations
OTTHUMP00000032249|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1
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Interactome
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Disease
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