ABCG2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
ABCG2 transfected lysate.
Western Blot
Lane 1: ABCG2 transfected lysate ( 72.3 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ABCG2 full-length
Host
Human
Theoretical MW (kDa)
72.3
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ABCG2 antibody (H00009429-B01) by Western Blots.
SDS-PAGE Gel
ABCG2 transfected lysate.
Western Blot
Lane 1: ABCG2 transfected lysate ( 72.3 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ABCG2
Entrez GeneID
9429GeneBank Accession#
NM_004827.2Protein Accession#
-Gene Name
ABCG2
Gene Alias
ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, MGC102821, MRX, MXR, MXR1
Gene Description
ATP-binding cassette, sub-family G (WHITE), member 2
Omim ID
603756Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq
Other Designations
ABC transporter|ATP-binding cassette transporter G2|ATP-binding cassette, sub-family G, member 2|breast cancer resistance protein|mitoxantrone resistance protein|placenta specific MDR protein
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Interactome
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Pathway
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Disease
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