ECEL1 (Human) Recombinant Protein (P01)
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Specification
Product Description
Human ECEL1 full-length ORF ( AAH50453.2, 1 a.a. - 775 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MEPPYSLTAHYDEFQEVKYVSRCGAGGARGASLPPGFPLGAARSATGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQLANITVSEYDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
114.2
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ECEL1
Entrez GeneID
9427GeneBank Accession#
BC050453.1Protein Accession#
AAH50453.2Gene Name
ECEL1
Gene Alias
DINE, ECEX, XCE
Gene Description
endothelin converting enzyme-like 1
Omim ID
605896Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the M13 family of endopeptidases. In general, M13 family members are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. This gene is expressed specifically in the central nervous system and its protein localizes predominately to the endoplasmic reticulum or, in trace amounts, to the cell surface. Disruption of this gene in mouse embryonic stem cells results in neonatal lethality due to respiratory failure shortly after birth. Based on the specific expression of this gene and the phenotype of the gene deficiency in mouse embryos, it is suggested that this protein plays a critical role in neural regulation of the respiratory system. This gene has multiple pseudogenes. [provided by RefSeq
Other Designations
OTTHUMP00000164361|X converting enzyme|damage induced neuronal endopeptidase
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Interactome
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Publication Reference
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Finding a reliable assay for soluble neprilysin.
Oi Wah Liew, Timothy C R Prickett, Elena Revuelta-López, Samantha S M Ling, Adriana Cserkóová, Josep Lupón, Jessica Y X Ng, Jenny P C Chong, Shera Lilyanna, Siew-Pang Chan, Qifeng Lin, Teck K Lim, Qingsong Lin, Jaume Barallat, Antoni Bayés-Genís, A Mark Richards.
Clinical Biochemistry 2022 Jun; 104:51.
Application：Quant, Human, Plasma.
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Finding a reliable assay for soluble neprilysin.
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