Immunoprecipitation of ZFYVE9 transfected lysate using anti-ZFYVE9 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with ZFYVE9 MaxPab rabbit polyclonal antibody (D01) (H00009372-D01).
This gene encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq
MAD homolog interacting protein,MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor,MADH-interacting protein,OTTHUMP00000009739,OTTHUMP00000009740,OTTHUMP00000009741,mothers against decapentaplegic homolog interact