Products

Western Blot (Recombinant protein)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunoperoxidase of monoclonal antibody to SLC9A3R1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged SLC9A3R1 is 0.3 ng/ml as a capture antibody.

ELISA

In situ Proximity Ligation Assay (Cell)

Proximity Ligation Analysis of protein-protein interactions between PDGFRB and SLC9A3R1. Huh7 cells were stained with anti-PDGFRB rabbit purified polyclonal 1:1200 and anti-SLC9A3R1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Entrez GeneID

9368

GeneBank Accession#

NM_004252

Protein Accession#

NP_004243.1

Gene Name

SLC9A3R1

Gene Alias

EBP50, NHERF, NHERF1, NPHLOP2

Gene Description

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1

Omim ID

604990

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer

Other Designations

sodium/hydrogen exchanger regulatory factor 1|solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1