PTTG1 monoclonal antibody (M23), clone 3H8
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant PTTG1.
Immunogen
PTTG1 (NP_004210, 93 a.a. ~ 113 a.a) synthetic peptide.
Sequence
CKTVKAKSSVPASD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (71); Rat (71)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — PTTG1
Entrez GeneID
9232GeneBank Accession#
NM_004219Protein Accession#
NP_004210Gene Name
PTTG1
Gene Alias
EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1
Gene Description
pituitary tumor-transforming 1
Omim ID
604147Gene Ontology
HyperlinkGene Summary
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq
Other Designations
ESP1-associated protein 1|OTTHUMP00000160845|pituitary tumor-transforming protein 1|securin|tumor-transforming protein 1
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Interactome
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Disease
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