LRAT monoclonal antibody (M01), clone 1A11
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant LRAT.
Immunogen
LRAT (AAH31053.1, 1 a.a. ~ 230 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80); Rat (78)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged LRAT is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — LRAT
Entrez GeneID
9227GeneBank Accession#
BC031053Protein Accession#
AAH31053.1Gene Name
LRAT
Gene Alias
MGC33103
Gene Description
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Omim ID
604863Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq
Other Designations
lecithin retinol acyltransferase
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Interactome
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Pathway
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Disease
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Publication Reference
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FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and LRAT.
Guignard TJ, Jin M, Pequignot MO, Li S, Chassigneux Y, Chekroud K, Guillou L, Richard E, Hamel CP, Brabet P.
The Journal of Biological Chemistry 2010 Jun; 285(24):18759.
Application:WB-Ce, WB-Tr, Insect, Pig, RPE, Sf9 cells.
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FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and LRAT.
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