Western blot analysis of SLC33A1 over-expressed 293 cell line, cotransfected with SLC33A1 Validated Chimera RNAi ( Cat # H00009197-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with SLC33A1 monoclonal antibody (M07), clone 3A4 (Cat # H00009197-M07 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The encoded protein is required for the formation of O-acetylated (Ac) gangliosides. It is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Studies indicate that the protein is localized to the cytoplasm. [provided by RefSeq
acetyl-Coenzyme A transporter,acetyl-coenzyme A transporter,spastic paraplegia 42 (autosomal dominant)