Western blot analysis of ZW10 over-expressed 293 cell line, cotransfected with ZW10 Validated Chimera RNAi ( Cat # H00009183-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with ZW10 monoclonal antibody (M05), clone 2E5 (Cat # H00009183-M05 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. [provided by RefSeq
ZW10 homolog, centromere/kinetochore protein,centromere/kinetochore protein zw10,zeste white 10 homolog